New evidence of glyphosate hepatotoxicity, particularly its impact on circadian rhythm disruption at real exposure levels, is the focus of a groundbreaking study by Xiao et al. (2025), published in Food and Chemical Toxicology.

This research reveals thatglyphosate exposure in mice alters the hepatic circadian clock system, significantly impairing glucose and lipid metabolism in the liver. The study uncovers a previously unknown mechanism of glyphosate toxicity that may be relevant to environmental and dietary exposure in humans.

These findings highlight the potential of chronic exposure to low levels of glyphosate to contribute to metabolic disorders, raising urgent questions about the long-term health effects of the world’s most widely used herbicide.